Some scientists are trying to develop a method of slimming with a fun way, chewing gum.
This method aims to increase the release of the hormone PYY, which creates a sense of satiety in the body.
Robert Doyle, a chemist from Syracuse University who led the research, said the hormone PYY is part of the body’s chemical systems that regulate appetite and energy. The release of this hormone increases with the addition of caloric intake. The study revealed, when a person eating or exercising, PYY is released into the bloodstream increases.
While previous studies mentioned, those who are obese have lower concentrations of PYY in the bloodstream, both when fasting and after meals. This is when compared with those with normal body weight.
“PYY is a hormone-suppressing appetite,” said Doyle. “When taken orally, these hormones will be destroyed in the stomach, while not destroyed will be difficult to cross into the bloodstream through the intestines.”
Collaborating with researchers from Murdoch University in Australia, Doyle began to develop a way to disguise the hormone so that when consumed orally, managed to reach the bloodstream, without experiencing any problems in the digestive organs.
Several years ago, Doyle developed a way to use vitamin B12 for oral insulin delivery. B12 is able to pass through the digestive system with relative ease and take insulin, or other substances, into the bloodstream.
Doyle also will adopt the system of delivery of insulin with B12 supplement. “The first phase of this study is to show that we improve the relevant levels of PYY into the bloodstream clinically,” he said as quoted by the Times of India. “We’ve done it, and we are very happy with the outcome.”
The next step is to find a way to adopt a system of B12-PYY to other media such as chewing gum or oral tablets. If successful, this would be a safe nutritional supplement to help a person lose weight. Just when someone is eating nicotine-laced chewing gum to help escape from addictive smoking.
The study was published in the Journal of Medicinal Chemistry American Chemical Society.